Monday Night Football FanDuel Picks: NFL DFS lineup advice for Week 13 49ers-Bills single-game tournaments

Written By Jacob Camenker

The Bills and 49ers are both battling for playoff positioning on Monday Night Football in Week 13. After wins by the Dolphins and Patriots, the Bills need to win to maintain their lead atop the AFC East. Meanwhile, the 49ers at 5-6 are just a half-game out of a tie for the NFC's seventh seed with the Vikings. This game will mean a lot to both teams, and with the 49ers getting healthier and the Bills sporting a strong offense, NFL DFS owners will be excited about the potential lineup combinations that can be used in this game. Our FanDuel Single-game lineup will try to differentiate ourselves from the pack by taking on both QBs and heavily leaning on a couple value plays.

Josh Allen and Nick Mullens will both be included in this lineup. Allen is an obvious choice and will be among the highest-owned players on this slate, but Mullens will give us some lineup differentiation. Many will fade the 49ers' current starter and usual backup, but he is in a good matchup and could help keep the 49ers close. Grabbing Mullens at a price $1,000 cheaper than Raheem Mostert allows us to spend up for some potential top plays that could give this lineup a massive edge and a lot of opportunities for double points.

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FanDuel Single-Game Picks: 49ers vs. Bills

MVP (1.5x points): Josh Allen, Bills ($16,500)

Josh Allen will probably be the highest-owned player on this slate, and he well may be the top MVP used, as well. That said, we're going to trust him because there aren't a lot of other good options for this spot. Allen is averaging 24.17 FanDuel points per game this season, and he has exceeded 25 FD points six times. His ceiling his high, and his rushing floor (28.3 yards and 0.5 rushing TDs per game) will make his floor high, too. That's the kind of guy you want in your MVP spot in these single-game matchups.

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FLEX: Nick Mullens, 49ers ($13,000)

Unlike Allen, Mullens hasn't been prolific this year. In each of his four most recent starts, Mullens has seen his FanDuel point total decrease. He has just one multi-TD game this year, and that came against the Seahawks' weak secondary. So, why would we start Mullens? Well, his value is solid at just $13K, and the Bills have allowed a lot of FanDuel points to QBs this year. Specifically, the Bills have allowed 20.9 FD points per game, seventh most, and that that is largely because they have allowed a league-high six rushing TDs to QBs this year. Mullens isn't much of a runner, but perhaps if the 49ers get down near the goal line, they'll design a play to take advantage of this or at least have him out on a bootleg. Either way, the Bills are a decent matchup and he's a bit underpriced, so we'll take advantage of this rare opportunity to pick up two QBs without spending down too much.

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FLEX: Deebo Samuel, 49ers ($12,000)

Samuel had his first huge game of the year against the Rams in Week 12. He was targeted 13 times, caught 11 passes, and put up a whopping 133 yards. This was despite playing a very tough Rams defense without the services of Brandon Aiyuk. Samuel should continue to get a lot of targets and plays designed to get the ball in his hands since he's so good after the catch. The Bills have been solid against WRs this year, but if Samuel can produce against Jalen Ramsey, he should be able to do the same against Tre'Davious White.

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FLEX: Brandon Aiyuk, 49ers ($11,000)

Like Samuel, Aiyuk is very good after the catch, and he is now healthy after a stay on the COVID list. In his past two games, Aiyuk has averaged 12 targets, 7.5 catches, 83 yards, and a TD. He was showing a strong rapport with Mullens before he was sidelined, and with Samuel back, he will face even less attention. Kyle Shanahan will certainly scheme up ways to get Aiyuk the ball, and like Samuel, if he can do damage after the catch, the reward for our lineup could be immense.

Quarterback | Running back | Wide receiver | Tight end | D/ST | Kicker

FLEX: Jordan Reed, 49ers ($7,500)

Reed is one of the most underpriced players on the slate. His recent production hasn't been great, as he has just eight catches for 83 yards in his past three games, but he has seen six targets in back-to-back games. The opportunities are there for Reed, and the Bills haven't been good against TEs this year. Entering Week 13, they had allowed 709 receiving yards to the position, which was second only to the Bengals (718 yards before Week 13). Reed should have a chance to rack up some yards if Mullens looks his way enough, and by having Reed, Samuel, and Aiyuk, we have the three best pass-catchers on the 49ers to stack with Mullens. That gives this lineup a ton of upside.

Quarterback | Running back | Wide receiver | Tight end | D/ST | Kicker

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